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KMID : 0861020180330020009
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Korea Journal of Herbology
2018 Volume.33 No. 2 p.9 ~ p.18
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Evaluation on Pharmacological Effects and Compound Contents of Hwangryunhaedok-tang formulation for Tablet
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Lee Ji-Beom
Choi Hye-Min
Kim Jong-Beom
Kim Jung-Ok
Moon Sung-Ok
Lee Hwa-Dong
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Abstract
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Objectives : Hwangryunhaedok-tang (HRHDT) is one of the well-known prescription herbal drugs of Korean herbal medicine, which has been widely used for the treatment of various bacterial and inflammatory diseases. This study was conducted in order to develop the tablet formulations of HRHDT and compare its efficacy with the other commercial formulations.
Methods : Corresponding herbal medicines comprising of HRHDT were extracted with water for 3 hr at 95~100℃ and then vacuum dried. Subsequently, some pharmaceutical excipients such as microcrystalline cellulose, croscarmellose sodium, magnesium stearate, etc were used to prepare the HRHDT tablets. The contents with characterizing components of HRHDT tablet was compared with the HRHDT decoction. The contents of characterizing components were analyzed with HPLC. Furthermore, we investigated the anti-inflammatory and anti-oxidative abilities of two different commercial HRHDT granules (HJP-1 and HJP-2) and were compared with that of the formulated HRHDT tablets. The anti-oxidant properties of HRHDR were studied using the 1,1-diphenyl-2-picryhydrazyl (DPPH) radical, contents of total flavonoid and polyphenol. In addition, based on this result the anti-inflammatory effects have verified by mechanism from LPS- treated Raw264.7 macrophages.
Results : The results demonstrated that HRHDT tablets showed more anti-inflammatory and anti-oxidative effects than HJP-1, HJP-2. Moreover, it showed more superior effects in terms of dose, usability and stability than the granules.
Conclusion : Hence, we concluded that in order to improve the quality and efficacy of the Korean herbal medicine, it is necessary to develop appropriate methods and establish standardized techniques for the development of good formulations.
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KEYWORD
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Hwangryunhaedok-tang, Tablets, Formulation, Anti-oxidative, Anti-infalmmatory
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